Monoamine Oxidase Inhibitors: Use of phentermine is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis.
Alcohol: Concomitant use of alcohol with phentermine may result in an adverse drug reaction.
Insulin and Oral Hypoglycemic Medications: Requirements may be altered.
Adrenergic Neuron Blocking Drugs: Phentermine may decrease the hypotensive effect of adrenergic neuron blocking drugs.